# 221 N Main Street, Hannibal, MO 63401

> **TL;DR:** commercial, $305,000 ($49/sqft), built 1860, 6,216 sqft.
> A/C. Est. $1,631/mo.

## Property at a Glance

| Attribute | Value |
|-----------|-------|
| Price | $305,000 |
| Price/sqft | $49 |
| Square Feet | 6,216 |
| Year Built | 1860 |
| Lot Size | 2,570 sqft (0.06 acres) |
| Stories | 3 |
| Property Type | Commercial (Retail) |
| Status | Active |
| Days on Market | 0 |

## Estimated Monthly Costs

| Category | Amount |
|----------|--------|
| Principal & Interest (20% down, 30-year at 6.5%) | $1,542 |
| Estimated Insurance | $89 |
| **Total** | **$1,631** |

## Key Amenities

- A/C

## Property Highlights

- Built in 1860
- 0.06 acre lot
- 3 stories

## Description

### Agent Description
WELL BELOW APPRAISED VALUE!!! Excellent Opportunity to own your own building in Historic Downtown Hannibal. North Main Street attracts visitors and locals to shops, restaurants, and most of all the Mark Twain Boyhood Home and Museum properties. 221 North Main has had a substantial rehab around 2010. Storefront restoration, new mechanical systems, roofing, interior remake, and lighting. Second floor has potential for additional retail square footage. 3 HVAC units, side entry off Bird Street and includes two private concrete parking pads. Over 4000 square feet of finished space. Be apart of Hannibal's tourist community. Location: Downtown, High Traffic, Retail Center

## Location

- **Address:** 221 N Main Street, Hannibal, MO 63401
- **County:** Marion
- **Neighborhood:** City/Hannibal
- **Coordinates:** 39.711123, -91.356854
- **Google Maps:** https://www.google.com/maps?q=39.711123,-91.356854

## Listing Agent

- **Name:** Sue-ann Westhoff
- **Brokerage:** Prestige Realty, Inc.
- **Broker Phone:** (573) 221-8171 x11

## Photos

![221 N Main Street - Photo 1](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f535013623r.jpg)

![221 N Main Street - Photo 2](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3942398915r.jpg)

![221 N Main Street - Photo 3](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2629351924r.jpg)

![221 N Main Street - Photo 4](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f4281556213r.jpg)

![221 N Main Street - Photo 5](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3089212767r.jpg)

![221 N Main Street - Photo 6](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3597446627r.jpg)

![221 N Main Street - Photo 7](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2338721730r.jpg)

![221 N Main Street - Photo 8](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f774429085r.jpg)

![221 N Main Street - Photo 9](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f1992502344r.jpg)

![221 N Main Street - Photo 10](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f44474651r.jpg)

![221 N Main Street - Photo 11](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3842326380r.jpg)

![221 N Main Street - Photo 12](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f705879378r.jpg)

![221 N Main Street - Photo 13](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2968862632r.jpg)

![221 N Main Street - Photo 14](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f691266215r.jpg)

![221 N Main Street - Photo 15](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2372757810r.jpg)

![221 N Main Street - Photo 16](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3962721854r.jpg)

![221 N Main Street - Photo 17](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f1475187451r.jpg)

![221 N Main Street - Photo 18](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f1276815885r.jpg)

![221 N Main Street - Photo 19](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2785370944r.jpg)

![221 N Main Street - Photo 20](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f1810315788r.jpg)

![221 N Main Street - Photo 21](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3134208589r.jpg)

![221 N Main Street - Photo 22](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2562160204r.jpg)

![221 N Main Street - Photo 23](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f2671186579r.jpg)

![221 N Main Street - Photo 24](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f4178036759r.jpg)

![221 N Main Street - Photo 25](http://lh.rdcpix.com/4843fb71d0f917cc69f639d13125d31dl-f3378327701r.jpg)

---

**MLS#:** 25018821 | **Updated:** 2026-10-20
**Source:** listhub

*Copyright © 2026 Mid America Regional Information Systems, Inc. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.*

[View on PropertySimple](https://www.propertysimple.ai/listing/221-n-main-street-hannibal-mo-63401-89a77ffb72f44a8ca01cbb43775c8e87)

---

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